The treatment tends to work best on pigmentation caused by sun damage, hormones, or acne scarring, and it typically improves overall clarity and glow rather than dramatically shifting your fundamental skin tone
For instance, it has been shown that NOS activity is necessary for calcium-induced activation of the Akt pathway (involved in translation initiation and subsequent muscle protein synthesis)
Molecules 19 (8), 1259112618 (2014) Toma, V.A., Tigu, A.B., Farca, A.D., Sevastre, B., Taulescu, M., Gherman, A.M.R., et al.: New aspects towards a molecular understanding of the allicin immunostimulatory mechanism via Colec12, MARCO, and SCARB1 receptors
Moreover, IL-2-induced constitutively active STAT5 antagonizes the T cell exhaustion program driven by the transcription factor Tox